منابع مشابه
Hypercalcemia of Malignancy
CASE STUDY A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic...
متن کاملHumoral Hypercalcemia of Malignancy
Secretion by tumor cells of circulating bone-resorbing factors may frequently underlie the hypercalcemia that occurs in patients with malignancy. Efforts to identify the responsible mediators have been hampered by a lack of available human tumor cell systems suitable for study of the pathogenesis of the humoral hypercalcemia syndrome. We have established a transitionalcell carcinoma (TCC) line ...
متن کاملHypercalcemia of malignancy: Part II.
Oncology nurses are responsible for the ongoing assessment of hypercalcemia, including reviewing laboratory findings as well as evaluating patient symptomatology. Abnormal serum creatinine, calcium, electrolytes, magnesium, and phosphate levels and symptoms such as constipation, lethargy, and weakness may alert clinicians to problems with this oncologic emergency. Resolution of hypercalcemia is...
متن کاملHypercalcemia of malignancy: Part I.
Digital Object Identifier: 10.1188/04.CJON.209-210 Hypercalcemia is a metabolic condition that occurs when the serum calcium level rises above the normal range of 9–11 mg/dl (Myers, 2001; Smith, 2000). It is a complex metabolic oncologic emergency that can be life threatening. This column is the first of a two-part series about hypercalcemia of malignancy (HCM). Part I focuses on the pathophysi...
متن کاملMalignancy-Induced Hypercalcemia—Diagnostic Challenges
Hypercalcemia in children is a rare metabolic finding. The clinical picture is usually non-specific, and the etiology includes several entities (metabolic, nutritional, drug-induced, inflammatory, cancer-associated, or genetic) depending on the age at presentation, but severe hypercalcemia is associated mainly with malignancy in childhood and sepsis in neonates. Severe parathyroid hormone (PTH)...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1988
ISSN: 0021-9738
DOI: 10.1172/jci113555